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KMID : 0061119840120000102
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Bulletin of the Clinical Research Institute
1984 Volume.12 No. 0 p.102 ~ p.102
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Effects of UVB on the Induction and Elicitation of DNCB Contact Sensitivity in Guinea Pigs
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Chyung, Eun-Jung
Choi, Shi-Ryong/Kim, Chung-Won/Houh, Won
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Abstract
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The aims of study presented here were to determine dose-dependent effects of UVB irradiation on CHS reaction and comparative effects of UVB on the induction and elicitation on guinea pigs. Pre-induction exposure to either suberythemal or supraerythemal doses; of UVB resulted in suppression of CHS (53.47% & 57.64%) compared to positive control (79.86%). However, suberythemal doses of UVB generated a more potent suppression than supraerythemal doses. Pre-elicitation exposure to suberythemal doses of UVB on the elicitation sites and adjacent to elicitation sites resulted in suppressed CHS reactions in both groups (0.429,D& 56.25%). When he reaction by UVB was eliminated from the cutaneous reaction elicited in guinea pigs sensitized to DNCR, by UVB irradiation on the adjacent to elicitation sites, generated a more potent suppression than that UVB was directly irradiated on the elicitation sites.
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KEYWORD
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